Treatment of Hepatitis C Virus (HCV) Genotype 1 Disease
نویسندگان
چکیده
منابع مشابه
Effect of hepatitis C virus (HCV) genotype on HCV and HIV-1 disease.
The relationship between hepatitis C virus (HCV) genotype and HCV and human immunodeficiency virus (HIV) type 1 disease is not well defined. The present study analyzed data from a cohort of 207 HIV-1-infected and 126 HIV-1-uninfected children and adolescents with hemophilia who enrolled in the Hemophilia Growth and Development Study and were followed for 7 years. The mean HCV RNA level was high...
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Background: Detection of hepatitis C virus specific antibodies is the initial step in chronic HCV diagnosis. HCV NS4B is among the most immunogenic HCV antigens and has been widely used in commercial Enzyme Immunoassays (EIA). Additionally, NS4B, a key protein in the virus replication, can be an alternative target for antiviral therapy. Objectives: Development of a new method for high-level ex...
متن کاملFactors affecting serum concentrations of hepatitis C virus (HCV) RNA in HCV genotype 1-infected patients with chronic hepatitis.
The serum concentration of hepatitis C virus (HCV) RNA is usually stable (4 to 8 log(10) IU/ml) in untreated patients with chronic hepatitis C. While this baseline HCV RNA concentration ([HCV RNA](BL)) is predictive of a sustained virologic response to treatment, its determinants are only partially identified. We therefore analyzed the baseline characteristics of 2,472 HCV genotype 1-infected p...
متن کاملQuantification of hepatitis C virus (HCV) RNA in a multicenter study: implications for management of HCV genotype 1-infected patients.
Assessment of the viral load in hepatitis C virus (HCV) genotype 1-infected patients is critical before, during, and after antiviral therapy. In patients achieving a rapid virological response at week 4 of treatment, the viral load at the baseline is considered a predictive criterion of a sustained virological response 24 weeks after the discontinuation of treatment. A >or=2-log(10) drop in the...
متن کاملHepatitis C virus (HCV) infection: serum rheumatoid factor activity and HCV genotype correlate with cryoglobulin clonality.
Chronic hepatitis C virus (HCV) infection has only recently been recognized as the leading cause of mixed cryoglobulinemia.1,2 Rheumatoid factor B cells are part of the normal repertoire and significant titers of rheumatoid factors (RF) are induced during normal antiviral or antibacterial immune responses. Under the pressure of chronic antigen stimulation, RF repertoire is remodeled, and progre...
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ژورنال
عنوان ژورنال: Current Treatment Options in Infectious Diseases
سال: 2017
ISSN: 1534-6250
DOI: 10.1007/s40506-017-0124-x